THE ROLE OF PEPSINOGENS IN THE FORMATION OF GERD IN PATIENTS WITH COPD

The article presents data on the role of pepsinogen-1 and -2 bilirubin in formation gastroesophageal reflux disease (GERD) patients with chronic obstructive pulmonary (COPD). Clinical, biochemical, immunological research methods were used work. activity pepsinogens 1 2 saliva was determined all combined pathology. It has been established that presence concomitant GERD is an independent aggravating factor for function external respiration. In GERD, a significant increase acute phase parameters serum, indicating active systemic inflammation. Increased cytokine IL-6 IFNγ indicates activation cellular immune system, unregulated response supports inflammation bronchi even remission. levels IL-4 are compensatory nature, as inhibits production macrophages proinflammatory cytokines, including IL-6. Detection correlations between concentration total decrease respiration, namely FVC, FEV-1, well shortness breath allows us to consider possible marker respiratory bronchi, until obstruction. positive correlation allergic history, pepsinogen-2 cough, smoking, negative value FEV1 / markers non-acid bronchoobstruction